Donnie Darko
Gretchen Ross
Frank
Karen Pomeroy
Kitty Farmer
Elizabeth Darko
Rose Darko
Eddie Darko
Prof. Kenneth Monnitoff
Dr. Lilian Thurman
Jim Cunningham
Samantha Darko
Dr. Fisher
Bob Garland
Roberta Sparrow / Grandma Death
Joanie James
Cherita Chen
Principal Cole
Susie Bates
Emily Bates
David
Anne Fisher
Sean Smith
Seth Devlin
Ronald Fisher
Mystery Woman
Ricky Danforth
Police Officer
Lanky Kid
Man in Red Jogging Suit
Suzy Bailey
Linda Connie
Shanda Riesman
Kim
Beth Farmer
Passenger
Friend
Dorky Half-Sister
Leroy
Larry Riesman