Susan Murphy / Ginormica (voice)

B.O.B. (voice)

Dr. Cockroach Ph.D. (voice)

Gallaxhar (voice)

The Missing Link (voice)

General W.R. Monger (voice)

Derek Dietl (voice)

President Hathaway (voice)

Wendy Murphy (voice)

Carl Murphy (voice)

Computer (voice)

News Reporter (voice)

Katie (voice)

Private Bullhorn / Helicopter Pilot / Advisor Ortega (voice)

Commander / Advisor Smith (voice)

Secret Service Man #1 / Lieutenant (voice)

Wilson (voice)

Advisor Cole / Army Commander Jones (voice)

Advisor Wedgie (voice)

Technician Jerry (voice)

Advisor Ouaou / Mrs. Ronson / Female Advisor #2 / Panicked Guest (voice)

Soldier #4 / Pilot / Soldier #3 / News Technician (voice)

Soldier #1 / Advisor Jackson (voice)

Bridesmaid Candy (voice)

Advisor Hawk / Advisor Dither / Minister / Secret Service Man #2 / Mama Dietl (voice)

Cuthbert (voice)

Technician Bee (voice)