George Beard (voice)

Harold Hutchins (voice)

Mr. Krupp / Captain Underpants (voice)

Professor Poopypants (voice)

Melvin (voice)

Edith (voice)

Ms. Ribble (voice)

Mr. Rected (voice)

Tommy (voice)

Mr. Fyde (voice)

Ms. Dayken (voice)

George's Mom (voice)

Sad Girl (voice)

Mime (voice)

Officer McPiggly (voice)

Goodie Two-Shoes Girl (voice)

Nobel Moderator (voice)

Nobel Audience Member (voice)

Balloon Girl (voice)